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The team takes on the case of a woman living in an open marriage, who is stricken ill while dating her love. Meanwhile, House decides to determine if Sam is the woman for Wilson.

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Grey

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Derek and Addison's relationship is rocked to the core when a former friend comes to Seattle Grace and his presence promises to shake things up for a few members of the staff. Burke and Cristina's relationship is affected when one of her secrets is outted. Alex and Izzie are having similar reactions to their closet scenes during the Code Black crisis. On top of this a cocky doctor shows up to piss Derek off in all kinds of ways. A patient is suffering from constant orgasms and her condition sparks interesting conversations among the staff. George is trying to figure out how to get Meredith to see him as more than just a housemate. Another patient, that Derek is treating, is dealing with a rare disorder and needs his parents support and understanding. Burke has a patient who inspires him to talk to Meredith and Cristina about doing what they say they will. Meanwhile, Meredith learns more about her family (in fact maybe more than she may have wanted to know) through her parents.

While completing some community service Homer makes fast friends with Chief Wiggum. Meanwhile, Bart becomes obsessed with a new, addictive Japanese game.

A female agent is sent to evaluate Sarah's performance as Chuck's handler, when Chuck's feelings for her become an issue to General Beckman. However, the presence of a new agent causes complications. Meanwhile, Morgan, Jeff and Lester are trying to get invited to Captain Awesome's bachelor party.

Charlie runs into Chelsea's old friend Gail again. Alan gets a new female patient at his chiropractic office.