House tells Dr. Nolan about the case of a woman who had amnesia and a disease, and how he had to help solve both mysteries.

The team tries to diagnose a woman's fiancée, and she's surprised to learn the secrets that he's been keeping from her. Meanwhile, House decides to spend some musical free time with Chase and Foreman.

The team takes on the case of a woman living in an open marriage, who is stricken ill while dating her love. Meanwhile, House decides to determine if Sam is the woman for Wilson.

Sir William, who dwells in a isolated community of people living in a medieval style, is stricken ill and the team must check the village for environmental factors. Thirteen is intrigued by the patient's archaic standards of honor. Meanwhile, Wilson tries to reconcile with one of his ex-wives.

Princeton Plainsboro goes on lockdown after a newborn disappears from the nursery. House is trapped with an inquisitive patient, Foreman and Taub are sealed in the records room, Wilson and Thirteen play Truth or Dare, and Chase is locked in with a familiar face.

House and team tries to diagnose a high school senior suffering from blackouts and hallucinations, and are forced to take a controversial approach. Meanwhile, Wilson attempts to furnish his new condo, and Taub brings his personal life into the workplace.

Charlie and Alan hire Berta's sister to cater a party their mother has conned them into throwing for her.

The team tries to diagnose a famous blogger but discover that her insistence on communicating on the Internet about her case interferes with their ability to cure her. Meanwhile, House and Wilson each discover secrets about each other, and Chase is convinced to go on a date.

It's a day in the life of Cuddy when she has to deal with her personal and professional life, insurance contract negotiations, a thieving pharmaceutical technician, an ailing daughter, and House and his team.