Sir William, who dwells in a isolated community of people living in a medieval style, is stricken ill and the team must check the village for environmental factors. Thirteen is intrigued by the patient's archaic standards of honor. Meanwhile, Wilson tries to reconcile with one of his ex-wives.

Princeton Plainsboro goes on lockdown after a newborn disappears from the nursery. House is trapped with an inquisitive patient, Foreman and Taub are sealed in the records room, Wilson and Thirteen play Truth or Dare, and Chase is locked in with a familiar face.

House and team tries to diagnose a high school senior suffering from blackouts and hallucinations, and are forced to take a controversial approach. Meanwhile, Wilson attempts to furnish his new condo, and Taub brings his personal life into the workplace.

The team tries to diagnose a famous blogger but discover that her insistence on communicating on the Internet about her case interferes with their ability to cure her. Meanwhile, House and Wilson each discover secrets about each other, and Chase is convinced to go on a date.

It's a day in the life of Cuddy when she has to deal with her personal and professional life, insurance contract negotiations, a thieving pharmaceutical technician, an ailing daughter, and House and his team.

The team disagree on how to treat a college football player who wants to be cured in time to compete in the NFL tryouts. Meanwhile, Foreman's brother Marcus pays him a visit.

House decides to take on the case of a beautiful female executive based on her looks, and the other males on the team are equally smitten. Only Thirteen is able to remain unaffected as they try to determine the cause of the woman's illness. Meanwhile, House tries to resolve his past with a former medical school colleague he wronged

A drug dealer collapses during a sale, but refuses to reveal personal information to the team because it might incriminate him. Meanwhile, Foreman's teammates conspire to play a practical joke on him, while House and Wilson both aim their sights on an attractive new neighbor, Nora.

Wilson insists on treating the case of a friend and former patient, Tucker, who is suffering from paralysis of his right arm. However, he soon discovers that he can't separate his feelings from his professional attitude. Meanwhile, Cuddy tries to buy a new house.

It's Thanksgiving, and the team discover they have little to be thankful for in their personal lives. Meanwhile, House takes on the illness of a brilliant physicist who has rejected his intellect to work as a courier.